Synthesis of chiral sulfoximine-based thioureas and their application in asymmetric organocatalysis

• Marcus Frings,
• Isabelle Thomé and
• Carsten Bolm

Beilstein J. Org. Chem. 2012, 8, 1443–1451, doi:10.3762/bjoc.8.164

• catalysts in high overall yields without affecting the stereohomogeneity of the sulfur-containing core fragment. Keywords: anhydride opening; catalytic asymmetric Biginelli reaction; organocatalysis; sulfoximines; thioureas; Introduction Since their discovery in the middle of the last century